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Does adaptive protein evolution proceed by large or small steps at the amino acid level?

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posted on 2023-06-09, 17:16 authored by Juraj Bergman, Adam Eyre-WalkerAdam Eyre-Walker
A long-standing question in evolutionary biology is the relative contribution of large and small effect mutations to the adaptive process. We have investigated this question in proteins by estimating the rate of adaptive evolution between all pairs of amino acids separated by one mutational step using a McDonald-Kreitman type approach and genome-wide data from several Drosophila species. We find that the rate of adaptive evolution is highest amongst amino acids that are more similar. This is partly due to the fact that the proportion of mutations that are adaptive is higher amongst more similar amino acids. We also find that the rate of neutral evolution between amino acids is higher amongst more similar amino acids. Overall our results suggest that both the adaptive and non-adaptive evolution of proteins is dominated by substitutions between similar amino acids.

History

Publication status

  • Published

File Version

  • Accepted version

Journal

Molecular Biology and Evolution

ISSN

0737-4038

Publisher

Oxford University Press

Issue

5

Volume

36

Page range

990-998

Department affiliated with

  • Evolution, Behaviour and Environment Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2019-03-18

First Open Access (FOA) Date

2020-02-14

First Compliant Deposit (FCD) Date

2019-03-15

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