CD28null CD4 T-cell expansions in autoimmune disease suggest a link with cytomegalovirus infection

Bano, Aalia, Pera Rojas, Alejandra, Almoukayed, Ahmad, Clarke, Thomas H S, Kirmani, Sukaina, Davies, Kevin A and Kern, Florian (2019) CD28null CD4 T-cell expansions in autoimmune disease suggest a link with cytomegalovirus infection. F1000Research. ISSN 2046-1402

[img] PDF ([version 1; peer review: 2 approved]) - Published Version
Available under License Creative Commons Attribution.

Download (1MB)

Abstract

Immunosenescence is thought to contribute to the increase of autoimmune diseases in older people. Immunosenescence is often associated with the presence of an expanded population of CD4 T cells lacking expression of CD28 (CD28null). These highly cytotoxic CD4 T cells were isolated from disease-affected tissues in patients with rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, or other chronic inflammatory diseases and their numbers appeared to be linked to disease severity. However, we recently demonstrated that the common herpes virus, cytomegalovirus (CMV), not ageing, is the major driver of this subset of cytotoxic T cells. In this review, we discuss how CMV might potentiate and exacerbate autoimmune disease through the expansion of CD28null CD4 T cells.

Item Type: Article
Keywords: CD28 null, CD4 T cell, autoimmune disease, cytomegalovirus infection
Schools and Departments: Brighton and Sussex Medical School > Clinical and Experimental Medicine
Subjects: R Medicine
R Medicine > R Medicine (General)
R Medicine > R Medicine (General) > R852 Research. Experimentation
Depositing User: Sandy Gray
Date Deposited: 27 Mar 2019 09:43
Last Modified: 27 Mar 2019 09:43
URI: http://srodev.sussex.ac.uk/id/eprint/82824

View download statistics for this item

📧 Request an update