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Additive manufacturing of hydroxyapatite bone scaffolds via digital light processing and in vitro compatibility

journal contribution
posted on 2023-06-09, 17:30 authored by Zibo Liu, Huixin Liang, Tianshu Shi, Deqiao Xie, Ruoyu Chen, Xiao Han, Lida Shen, Chang WangChang Wang, Zongjun Tian
The bioceramic material hydroxyapatite (HA) is widely used in the field of bone repair. Based on additive manufacturing (AM) techniques, HA is fabricated with complex geometry to satisfy biomedical application requirements. Digital light processing (DLP) is a promising AM technique that is capable of producing HA parts with high accuracy and efficiency. The fabrication of HA parts using DLP is investigated in this study. Properties of the HA ceramic slurry and the process parameters of curing, debinding, and sintering are initially examined. The mechanical properties, porosity, and shrinkage of the sintered samples is then investigated. The experimental results show that ceramic samples with density above 90%, microhardness up to 270 HV, and flexural strength of 41.3?MPa can be manufactured using the DLP method. Hydroxyapatite bone scaffolds are then prepared with pore sizes of 300–600?µm, porosity of about 49.8%, and compressive strength of 15.25?MPa, and the scaffolds are cultured with osteoblast precursor cells to detect biocompatibility. Results illustrate that the produced scaffolds possess strong biocompatibility and can promote osteoblast proliferation, adhesion, and differentiation. The HA bone scaffolds fabricated by DLP AM show strong potential to fulfill a constructive role in the medical field of human bone repair.

History

Publication status

  • Published

Journal

Ceramics International

ISSN

0272-8842

Publisher

Elsevier

Issue

8

Volume

45

Page range

11079-11086

Department affiliated with

  • Engineering and Design Publications

Research groups affiliated with

  • Dynamics, Control and Vehicle Research Group Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2019-04-04

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