Modeling tracer kinetics in dynamic Gd-DTPA MR imaging

Tofts, Paul S. (1997) Modeling tracer kinetics in dynamic Gd-DTPA MR imaging. Journal of Magnetic Resonance Imaging, 7 (1). pp. 91-101. ISSN 1053-1807

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Three major models (from Tofts, Larsson, and Brix) for collecting and analyzing dynamic MRI gadolinium-diethylene-triamine penta-acetic acid (Gd-DTPA) data are examined. All models use compartments representing the blood plasma and the abnormal extravascular extracellular space (EES), and they are intercompatible. All measure combinations of three parameters; (1) kPSp is the influx volume transfer constant (min-1), or permeability surface area product per unit volume of tissue, between plasma and EES; (2) ve is the volume of EES space per unit volume of tissue (0 < ve < 1); and (3) K(ep), the efflux rate constant (min-1), is the ratio of the first two parameters (k(ep) = kPSp/ve). The ratio K(ep) is the simplest to measure, requiring only signal linearity with Gd tracer concentration or, alternatively, a measurement of T1 before injection of Gd (T10). To measure the physiologic parameters kPSp and ve separately requires knowledge of T10 and of the tissue relaxivity R1 (approximately in vitro value).

Item Type: Article
Keywords: Animals Contrast Media/ pharmacokinetics Extracellular Space/metabolism Gadolinium DTPA Humans Image Enhancement/ methods Magnetic Resonance Imaging/ methods Models, Biological Organometallic Compounds/diagnostic use/ pharmacokinetics Pentetic Acid/ analogs & derivatives/diagnostic use/pharmacokinetics Permeability Radioactive Tracers Reproducibility of Results
Schools and Departments: Brighton and Sussex Medical School > Brighton and Sussex Medical School
Depositing User: Paul Stephen Tofts
Date Deposited: 28 Feb 2007
Last Modified: 30 Nov 2012 16:50
Google Scholar:651 Citations
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