Article

Murrell-Lagnado, Ruth and Frick, Manfred (2019) P2X4 and lysosome fusion. Current Opinion in Pharmacology. ISSN 1471-4892 (Accepted)

Murrell-Lagnado, Ruth (2018) A role for P2X4 receptors in lysosome function. Journal of General Physiology, 150 (2). pp. 185-187. ISSN 0022-1295

Srivats, Shyam, Balasuriya, Dilshan, Pasche, Mathias, Vistal, Gerard, Edwardson, J Michael, Taylor, Colin W and Murrell-Lagnado, Ruth D (2016) Sigma1 receptors inhibit store-operated Ca2+entry by attenuating coupling of STIM1 to Orai1. The Journal of Cell Biology, 213 (1). pp. 65-79. ISSN 0021-9525

Ruepp, Marc-David, Brozik, James A, de Esch, Iwan J P, Farndale, Richard W, Murrell-Lagnado, Ruth D and Thompson, Andrew J (2015) A fluorescent approach for identifying P2X1 ligands. Neuropharmacology, 98. pp. 13-21. ISSN 1873-7064

Hardege, Iris, Xu, Shengxin, Gordon, Richard D, Thompson, Andrew J, Figg, Nichola, Stowasser, Michael, Murrell-Lagnado, Ruth and O'Shaughnessy, Kevin M (2015) Novel insertion mutation in KCNJ5 channel produces constitutive aldosterone release from H295R cells. Molecular Endocrinology, 29 (10). pp. 1522-30. ISSN 1944-9917

Cao, Qi, Zhong, Xi Zoë, Zou, Yuanjie, Murrell-Lagnado, Ruth, Zhu, Michael X and Dong, Xian-Ping (2015) Calcium release through P2X4 activates calmodulin to promote endolysosomal membrane fusion. Journal of Cell Biology, 209 (6). pp. 879-894. ISSN 1540-8140

Robinson, Lucy E, Shridar, Mitesh, Smith, Philip and Murrell-Lagnado, Ruth D (2014) Plasma membrane cholesterol as a regulator of human and rodent P2X7 receptor activation and sensitization. Journal of Biological Chemistry, 289. pp. 31983-31994. ISSN 0021-9258

Balasuriya, Dilshan, Srivats, Shyam, Murrell-Lagnado, Ruth D and Edwardson, J Michael (2014) Atomic force microscopy (AFM) imaging suggests that stromal interaction molecule 1 (STIM1) binds to Orai1 with sixfold symmetry. FEBS Letters, 588 (17). pp. 2874-2880. ISSN 0014-5793

Huang, Peng, Zou, Yuanjie, Zhong, Xi Zoë, Cao, Qi, Zhao, Kexin, Zhu, Michael X, Murrell-Lagnado, Ruth and Dong, Xian-Ping (2014) P2X4 forms functional ATP-activated cation channels on lysosomal membranes regulated by luminal pH. Journal of Biological Chemistry, 289. pp. 17658-17667. ISSN 0021-9258

Huang, Peng, Zou, Yuanjie, Zhong, Xi Zoë, Cao, Qi, Zhao, Kexin, Zhu, Michael X, Murrell-Lagnado, Ruth and Dong, Xian-Ping (2014) P2X4 forms functional ATP-activated cation channels on lysosomal membranes regulated by luminal pH. Journal of Biological Chemistry, 289 (25). pp. 17658-67. ISSN 1083-351X

Robinson, Lucy E and Murrell-Lagnado, Ruth D (2013) The trafficking and targeting of P2X receptors. Frontiers in Cellular Neuroscience, 7. p. 233. ISSN 1662-5102

Xu, Xing Jian, Boumechache, Miyyada, Robinson, Lucy E, Marschall, Viola, Gorecki, Dariusz C, Masin, Marianela and Murrell-Lagnado, Ruth D (2012) Splice variants of the P2X7 receptor reveal differential agonist dependence and functional coupling with pannexin-1. Journal of Cell Science, 125. pp. 3776-3789. ISSN 0021-9533

Stewart, Andrew P, Gómez-Posada, Juan Camilo, McGeorge, Jessica, Rouhani, Maral J, Villarroel, Alvaro, Murrell-Lagnado, Ruth D and Edwardson, J Michael (2012) The Kv7.2/Kv7.3 heterotetramer assembles with a random subunit arrangement. Journal of Biological Chemistry, 287. pp. 11870-11877. ISSN 0021-9258

Masin, Marianela, Young, Christopher, Lim, KoiNi, Barnes, Sara J, Xu, Xing Jian, Marschall, Viola, Brutkowski, Wojciech, Mooney, Elizabeth R, Gorecki, Dariusz C and Murrell-Lagnado, Ruth (2012) Expression, assembly and function of novel C-terminal truncated variants of the mouse P2X7 receptor: re-evaluation of P2X7 knockouts. British Journal of Pharmacology, 165. pp. 978-993. ISSN 0007-1188

Antonio, Ligia S, Stewart, Andrew P, Varanda, Wamberto A, Murrell-Lagnado, Ruth and Edwardson, J Michael (2012) AFM imaging reveals the assembly of a P2X receptor complex containing P2X2, P2X4 and P2X6 subunits. The Journal of Biological Chemistry, 102 (3S1). 336a-336s. ISSN 0021-9258

Antonio, L S, Stewart, A P, Xu, X J, Varanda, W A, Murrell-Lagnado, R D and Edwardson, J M (2011) P2X4 receptors interact with both P2X2 and P2X7 receptors in the form of homotrimers. British Journal of Pharmacology, 163 (5). pp. 1069-1077. ISSN 0007-1188

Gómez-Posada, Juan Camilo, Etxeberría, Ainhoa, Roura-Ferrer, Meritxell, Areso, Pilar, Masin, Marianela, Murrell-Lagnado, Ruth D and Villarroel, Alvaro (2010) A pore residue of the KCNQ3 potassium M-channel subunit controls surface expression. Journal of Neuroscience, 30 (27). pp. 9316-9323. ISSN 0270-6474

Barnes, Sara J, Masin, Marianela, Marschall, Viola, Mooney, Elizabeth, Young, Christopher, Lim, KoiNi, Gorecki, Dariusz C and Murrell-Lagnado, Ruth (2010) Characterisation of C-terminal-truncated P2X7 receptor splice variants. Purinergic Signalling, 6 (1S). p. 57. ISSN 1573-9538

Murrell-Lagnado, Ruth, Boumechache, Miyyada and Qureshi, Omar (2010) Endolysosomal targeting and function of mammalian P2X4 receptors. Purinergic Signalling, 6 (1S). p. 24. ISSN 1573-9538

Xu, Xing Jian, Masin, Marianela, Marschall, Viola and Murrell-Lagnado, Ruth (2010) Novel properties of the mouse P2X7k splice variant. Purinergic Signalling, 6 (1S). pp. 55-56. ISSN 1573-9538

Boumechache, Miyyada, Ali, Saira, Shahid, Sumayya, Masin, Marianela and Murrell-Lagnado, Ruth (2010) Structural and functional interaction between P2X(4), P2X(7) and pannexin-1. Purinergic Signalling, 6 (1). p. 73. ISSN 1573-9538

Nicke, Annette, Kuan, Yung-Hui, Masin, Marianela, Rettinger, Jürgen, Marquez-Klaka, Benjamin, Bender, Olaf, Górecki, Dariusz C, Murrell-Lagnado, Ruth D and Soto, Florentina (2009) A functional P2X7 splice variant with an alternative transmembrane domain 1 escapes gene inactivation in P2X7 knock-out mice. Journal of Biological Chemistry, 284. pp. 25813-25822. ISSN 0021-9258

Murrell-Lagnado, Ruth (2009) More cross-talk between purinergic receptors. Journal of Physiology, 587 (12). pp. 2713-2714. ISSN 0022-3751

Boumechache, Miyyada, Masin, Marianela, Edwardson, J Michael, Gorecki, Dariusz C and Murrell-Lagnado, Ruth (2009) Analysis of assembly and trafficking of native P2X(4) and P2X(7) receptor complexes in rodent immune cells. Journal of Biological Chemistry, 6. pp. 13446-13454. ISSN 0021-9258

Boumechache, Miyyada, Masin, Marianela, Edwardson, J Michael, Górecki, Dariusz C and Murrell-Lagnado, Ruth (2009) Analysis of assembly and trafficking of native P2X4 and P2X7 receptor complexes in rodent immune cells. Journal of Biological Chemistry, 284. pp. 13446-13454. ISSN 0021-9258

Boumechache, Miyyada, Masin, Masin, Paramasivam, Anbalakan and Murrell-Lagnado, Ruth (2008) Regulation of expression and trafficking of P2X4 and P2X7 receptors in immune cells. Purinergic Signalling, 4 (1). p. 180. ISSN 1573-9538

Murrell-Lagnado, Ruth D and Qureshi, Omar S (2008) Assembly and trafficking of P2X purinergic receptors (review). Molecular Membrane Biology, 25 (4). pp. 321-331. ISSN 0968-7688

Guo, Chang, Masin, Marianela, Qureshi, Omar S and Murrell-Lagnado, Ruth D (2007) Evidence for functional P2X4/P2X7 heteromeric receptors. Molecular Pharmacology, 72 (6). pp. 1447-1456. ISSN 0026-895X

Qureshi, Omar S, Paramasivam, Anbalakan, Yu, Jowie C H and Murrell-Lagnado, Ruth D (2007) Regulation of P2X4 receptors by lysosomal targeting, glycan protection and exocytosis. Journal of Cell Science, 120. pp. 3838-3849. ISSN 0021-9533

Barrera, Nelson P, Henderson, Robert M, Murrell-Lagnado, Ruth D and Edwardson, J Michael (2007) The stoichiometry of P2X2/6 receptor heteromers depends on relative subunit expression levels. Biophysical Journal, 93. pp. 505-512. ISSN 0006-3495

Ormond, Susan J, Barrera, Nelson P, Qureshi, Omar S, Henderson, Robert M, Edwardson, J Michael and Murrell-Lagnado, Ruth D (2006) An uncharged region within the N terminus of the P2X6 receptor inhibits its assembly and exit from the endoplasmic reticulum. Molecular Pharmacology, 69 (5). pp. 1692-1700. ISSN 0026-895X

Royle, Stephen J, Qureshi, Omar S, Bobanović, Laura K, Evans, Philip R, Owen, David J and Murrell-Lagnado, Ruth D (2005) Non-canonical YXXGPhi endocytic motifs: recognition by AP2 and preferential utilization in P2X4 receptors. Journal of Cell Science, 118. pp. 3073-3080. ISSN 0021-9533

Barrera, Nelson P, Ormond, Susan J, Henderson, Robert M, Murrell-Lagnado, Ruth D and Edwardson, J Michael (2005) Atomic force microscopy imaging demonstrates that P2X2 receptors are trimers but that P2X6 receptor subunits do not oligomerize. The Journal of Biological Chemistry, 280. pp. 10759-10765. ISSN 0021-9258

Royle, Stephen J and Murrell-Lagnado, Ruth D (2003) Constitutive cycling: a general mechanism to regulate cell surface proteins. BioEssays, 25 (1). pp. 39-46. ISSN 0265-9247

Guo, Yuan, Waldron, Gareth J and Murrell-Lagnado, Ruth (2002) A role for the middle C terminus of G-protein-activated inward rectifier potassium channels in regulating gating. Journal of Biological Chemistry, 277. pp. 48289-48294. ISSN 0021-9258

Royle, Stephen J, Bobanović, Laura K and Murrell-Lagnado, Ruth D (2002) Identification of a non-canonical tyrosine-based endocytic motif in an ionotropic receptor. Journal of Biological Chemistry, 277. pp. 35378-35385. ISSN 0021-9258

Bobanovic, Laura K, Royle, Stephen J and Murrell-Lagnado, Ruth D (2002) P2X receptor trafficking in neurons is subunit specific. Journal of Neuroscience, 22 (12). pp. 4814-4824. ISSN 0270-6474

MacVinish, L J, Guo, Y, Dixon, A K, Murrell-Lagnado, R D and Cuthbert, A W (2001) Xe991 reveals differences in K(+) channels regulating chloride secretion in murine airway and colonic epithelium. Molecular Pharmacology, 60 (4). pp. 753-760. ISSN 0026-895X

Ho, Ivan H M and Murrell-Lagnado, R D (1999) Molecular mechanism for sodium-dependent activation of G protein-gated K+ channels. Journal of Physiology, 520 (3). pp. 645-651. ISSN 0022-3751

Smith, Fiona M, Humphrey, Patrick P A and Murrell-Lagnado, Ruth D (1999) Identification of amino acids within the P2X2 receptor C-terminus that regulate desensitization. Journal of Physiology, 520 (1). pp. 91-99. ISSN 0022-3751

Ho, Ivan H M and Murrell-Lagnado, R D (1999) Molecular determinants for sodium-dependent activation of G protein-gated K+ channels. Journal of Biological Chemistry, 274. pp. 8639-8648. ISSN 0021-9258

Murrell-Lagnado, Ruth D (1999) Potassium ion channel inactivation peptides. Methods in Enzymology, 294. pp. 640-649. ISSN 0076-6879

Stevens, Edward B, Woodward, Robert, Ho, Ivan H M and Murrell-Lagnado, Ruth (1997) Identification of regions that regulate the expression and activity of G protein-gated inward rectifier K+ channels in Xenopus oocytes. Journal of Physiology, 503 (3). pp. 547-562. ISSN 0022-3751

Simon, Joseph, Kidd, Emma J, Smith, Fiona M, Chessell, Iain P, Murrell-Lagnado, Ruth, Humphrey, Patrick P A and Barnard, Eric A (1997) Localization and functional expression of splice variants of the P2X(2) receptor. Molecular Pharmacology, 52 (2). pp. 237-248. ISSN 0026-895X

Woodward, Robert, Stevens, Edward B and Murrell-Lagnado, Ruth D (1997) Molecular determinants for assembly of G-protein-activated inwardly rectifying K+ channels. Journal of Biological Chemistry, 272. pp. 10823-10830. ISSN 0021-9258

Murrell-Lagnado, Ruth D and Aldrich, Richard W (1993) Interactions of amino terminal domains of Shaker K channels with a pore blocking site studied with synthetic peptides. The Journal of General Physiology (JGP), 102 (6). pp. 949-975. ISSN 0022-1295

Murrell-Lagnado, Ruth D and Aldrich, Richard W (1993) Energetics of Shaker K channels block by inactivation peptides. The Journal of General Physiology (JGP), 102 (6). pp. 977-1003. ISSN 0022-1295

Murrell, Ruth D and Tolkovsky, Aviva M (1993) Role of voltage-gated Ca2+ channels and intracellular Ca2+ in rat sympathetic neuron survival and function promoted by high K+ and cyclic AMP in the presence or absence of NGF. European Journal of Neuroscience, 5 (10). pp. 1261-1272. ISSN 0953-816X

Murrell, R D, Braun, M S and Haydon, D A (1991) Actions of n-alcohols on nicotinic acetylcholine receptor channels in cultured rat myotubes. Journal of Physiology, 437 (1). pp. 431-448. ISSN 0022-3751

Murrell, R D and Haydon, D A (1991) Actions of n-alcohols on nicotinic acetylcholine receptor ion channels in cultured rat muscle cells. Annals of the New York Academy of Sciences, 625. pp. 365-374. ISSN 0077-8923

Suidan, H S, Murrell, R D and Tolkovsky, A M (1991) Carbachol and bradykinin elevate cyclic AMP and rapidly deplete ATP in cultured rat sympathetic neurons. Molecular Biology of the Cell, 2 (1). pp. 13-25. ISSN 1059-1524

Murrell, R D and Tolkovsky, A M (1990) Chronic depolarization causes a decrease in functional calcium channels expressed in cultured rat sympathetic neurons. Journal of Physiology, 426 (S). p. 62. ISSN 0022-3751

Suidan, H S, Murrell, R D and Tolkovsky, A M (1990) The rise in cyclic-AMP levels in cultured rat superior cervical-ganglion neurons induced by bradykinin and carbachol is mediated via an increase in cytosolic calcium. Journal of Physiology, 425 (S). p. 72. ISSN 0022-3751

Tolkovsky, A M, Walker, A E, Murrell, R D and Suidan, H S (1990) Ca2+ transients are not required as signals for long-term neurite outgrowth from cultured sympathetic neurons. Journal of Cell Biology, 110 (4). pp. 1295-1306. ISSN 0021-9525

Braun, M, Haydon, D A and Murrell, R D (1989) The effects of n-alcohols on the nicotinic acetylcholine-receptor channel in cultured rat myotubes. Journal of Physiology, 418 (S). p. 37. ISSN 0022-3751

Elliott, J R, Murrell, R D and Haydon, D A (1987) Local anesthetic action of carboxylic esters: evidence for the significance of molecular volume and for the number of sites involved. Journal of Membrane Biology, 95 (2). pp. 143-149. ISSN 0022-2631

Elliott, J R, Haydon, D A and Murrell, R D (1986) The effects of carboxylic esters on Na current inactivation in axons of Loligo. Journal of Physiology, 380 (S). p. 22. ISSN 0022-3751

Jones, M S, Murrell, R D and Shaw, I C (1985) Excretion of sodium 2-mercaptoethanesulphonate (MESNA) in the urine of volunteers after oral dosing. European Journal of Cancer and Clinical Oncology, 21 (5). pp. 553-555. ISSN 0277-5379

Book Section

Murrell-Lagnado, Ruth D (2017) Regulation of P2X purinergic receptor signalling by cholesterol. In: Levitan, Irena (ed.) Sterol regulation of ion transport mechanisms. Current topics in membranes, 80 . Elsevier, pp. 211-232.