Article

Kenyon, Emma J, Kirkwood, Nerissa K, Kitcher, Siân R, O'Reilly, Molly, Derudas, Marco, Cantillon, Daire M, Goodyear, Richard J, Secker, Abigail, Baxendale, Sarah, Bull, James C, Waddell, Simon J, Whitfield, Tanya T, Ward, Simon E, Kros, Corné J and Richardson, Guy P (2017) Identification of ion-channel modulators that protect against aminoglycoside-induced hair cell death. Journal of Clinical Investigation Insight, 2 (24). ISSN 2379-3708

Kenyon, Emma J, Kirkwood, Nerissa K, Kitcher, Siân R, O'Reilly, Molly, Derudas, Marco, Cantillon, Daire M, Goodyear, Richard J, Secker, Abigail, Baxendale, Sarah, Bulley, James C, Waddell, Simon J, Whitfield, Tanya T, Ward, Simon E, Kros, Corné J and Richardson, Guy P (2017) Identification of ion-channel modulators that protect against aminoglycoside-induced hair-cell death. Journal of Clinical Investigation Insight, 2 (24). ISSN 2379-3708

Goodyear, Richard J, Lu, Xiaowei, Deans, Michael R and Richardson, Guy P (2017) A tectorin-based matrix and planar-cell-polarity genes are required for normal collagen-fibril orientation in the developing tectorial membrane. Development, 144. pp. 3978-3989. ISSN 0950-1991

Shaya, Oren, Binshtok, Udi, Hersh, Micha, Rivken, Dmitri, Weinreb, Sheila, Amir-Siberstein, Liat, Khamaisi, Bassma, Oppenheim, Olya, Desai, Ravi A, Goodyear, Richard J, Richardson, Guy P, Cheng, Christopher S and Sprinzak, David (2017) Cell-cell contact area affects Notch signaling and Notch-dependent patterning. Developmental Cell, 40 (5). pp. 505-511. ISSN 1534-5807

Marcotti, Walter, Corns, Laura F, Goodyear, Richard J, Rzadzinska, Agnieszka K, Avraham, Karen B, Steel, Karen P, Richardson, Guy P and Kros, Corné J (2016) The acquisition of mechano-electrical transducer current adaptation in auditory hair cells requires myosin VI. Journal of Physiology, 594 (13). pp. 3667-3681. ISSN 0022-3751

Legan, Kevin, Goodyear, Richard, Morin, Matias, Mencia, Angeles, Pollard, Hilary, Olavarrieta, Leticia, Korchagina, Julia Jurievna, Modiamo-Hoybjor, Silvia, Mayo, Fernando, Moreno, Felipe, Moreno-Pelayo, Miguel-Angel and Richardson, Guy (2014) Three deaf mice: mouse models for TECTA-based human hereditary deafness reveal domain-specific structural phenotypes in the tectorial membrane. Human Molecular Genetics, 23 (10). pp. 2551-2568. ISSN 0964-6906

Lukashkin, Andrei N, Legan, P Kevin, Weddell, Thomas D, Lukashkina, Victoria A, Goodyear, Richard J, Welstead, Lindsey J, Petit, Christine, Russell, Ian J and Richardson, Guy P (2012) A mouse model for human deafness DFNB22 reveals that hearing impairment is due to a loss of inner hair cell stimulation. Proceedings of the National Academy of Sciences of the United States of America, 109 (47). pp. 19351-19356. ISSN 1091-6490

Alagramam, Kumar N, Goodyear, Richard J, Geng, Ruishuang, Furness, David N, Van Aken, Alexander F J, Marcotti, Walter, Kros, Corné J and Richardson, Guy P (2011) Mutations in protocadherin 15 and cadherin 23 affect tip links and mechanotransduction in mammalian sensory hair cells. PLoS ONE, 6 (4). e19183. ISSN 1932-6203

Zheng, Jing, Miller, Katharine K., Yang, Tao, Hildebrand, Michael S., Shearer, A. Eliot, DeLuca, Adam P., Scheetz, Todd E., Drummond, Jennifer, Scherer, Steve E., Legan, P Kevin, Goodyear, Richard J, Richardson, Guy P, Cheatham, Mary Ann, Smith, Richard J. and Dallos, Peter (2011) Carcinoembryonic antigen-related cell adhesion molecule 16 interacts with alpha-tectorin and is mutated in autosomal dominant hearing loss (DFNA4). Proceedings of the National Academy of Sciences, 108 (10). pp. 4218-4223.

Nayak, Gowri, Goodyear, Richard J, Legan, P Kevin, Noda, Masaharu and Richardson, Guy P (2011) Evidence for multiple, developmentally regulated isoforms of Ptprq on hair cells of the inner ear. Developmental Neurobiology, 71 (2). pp. 129-141.

Goodyear, Richard J, Legan, P Kevin, Christiansen, Jeffrey R, Xia, Bei, Korchagina, Julia, Gale, Jonathan E, Warchol, Mark E, Corwin, Jeffrey T and Richardson, Guy P (2010) Identification of the Hair Cell Soma-1 Antigen, HCS-1, as Otoferlin. Journal of the Association for Research in Otolaryngology, 11 (4). pp. 573-586. ISSN 1525-3961

Goodyear, Richard J, Forge, Andy, Legan, P Kevin and Richardson, Guy P (2010) Asymmetric Distribution of Cadherin 23 and Protocadherin 15 in the Kinocilial Links of Avian Sensory Hair Cells. Journal of Comparative Neurology, 518 (21). pp. 4288-4297. ISSN 0021-9967

Kitajiri, Shin-ichiro, Sakamoto, Takeshi, Belyantseva, Inna A, Goodyear, Richard J, Stepanyan, Ruben, Fujiwara, Ikuko, Bird, Jonathan E, Riazuddin, Saima, Riazuddin, Sheikh, Ahmed, Zubair M, Hinshaw, Jenny E, Sellers, James, Bartles, James R, Hammer III, John A, Richardson, Guy P, Griffith, Andrew J, Frolenkov, Gregory I and Friedman, Thomas B (2010) Actin-Bundling Protein TRIOBP Forms Resilient Rootlets of Hair Cell Stereocilia Essential for Hearing. Cell, 141 (5). pp. 786-798. ISSN 0092-8674

Morín, Matías, Bryan, Keith E, Mayo-Merino, Fernando, Goodyear, Richard, Mencía, Ángeles, Modamio-Høybjør, Silvia, del Castillo, Ignacio, Cabalka, Jessica M, Richardson, Guy, Moreno, Felipe, Rubenstein, Peter A and Moreno-Pelayo, Miguel Ángel (2009) In vivo and in vitro effects of two novel gamma-actin (ACTG1) mutations that cause DFNA20/26 hearing impairment. Human Molecular Genetics, 18 (16). 075-3089. ISSN 0964-6906

Van Aken, Alexander F J, Atiba-Davies, Margaret, Marcotti, Walter, Goodyear, Richard J, Bryant, Jane E, Richardson, Guy P, Noben-Trauth, Konrad and Kros, Corné J (2008) TRPML3 mutations cause impaired mechano-electrical transduction and depolarization by an inward-rectifier cation current in auditory hair cells of varitint-waddler mice. Journal of Physiology, 586 (22). pp. 5403-5418. ISSN 0022-3751

Goodyear, Richard J, Gale, Jonathan E, Ranatunga, Kishani M, Kros, Corné J and Richardson, Guy P (2008) Aminoglycoside-Induced Phosphatidylserine Externalization in Sensory Hair Cells Is Regionally Restricted, Rapid, and Reversible. Journal of Neuroscience, 28 (40). pp. 9939-9952. ISSN 0270-6474

Van Aken, Alexander F J, Atiba-Davies, Margaret, Marcotti, Walter, Goodyear, Richard J, Bryant, Jane E, Richardson, Guy P, Noben-Trauth, Konrad and Kros, Corné J (2008) TRPML3 mutations cause impaired mechano-electrical transduction and depolarization by an inward-rectifier cation current in auditory hair cells of varitint-waddler mice. Journal of Physiology, 586 (22). pp. 5403-5418. ISSN 0022-3751

Moreno-Pelayo, Miguel Ángel, Goodyear, Richard J, Mencía, Ángeles, Modamio-Høybjør, Silvia, Legan, P Kevin, Olavarrieta, Leticia, Moreno, Felipe and Richardson, Guy P (2008) Characterization of a spontaneous, recessive, missense mutation arising in the Tecta gene. Journal of the Association for Research in Otolaryngology, 9 (2). pp. 202-214. ISSN 1525-3961

Modamio-Hoybjor, Silvia, Mencía, Ángeles, Goodyear, Richard, del Castillo, Ignacio, Richardson, Guy, Moreno, Felipe and Moreno-Pelayo, Miguel Ángel (2007) A mutation in CCDC50, a gene encoding an effector of epidermal growth factor-mediated cell signalling, causes progressive hearing loss. American Journal of Human Genetics, 80 (6). pp. 1076-1089. ISSN 0002-9297

Russell, Ian J, Legan, P Kevin, Lukashkina, Victoria A, Lukashkin, Andrei N, Goodyear, Richard J and Richardson, Guy P (2007) Sharpened cochlear tuning in a mouse with a genetically modified tectorial membrane. Nature Neuroscience, 10 (2). pp. 215-223. ISSN 1097-6256

Nayak, Gowri D, Ratnayaka, Helen S K, Goodyear, Richard J and Richardson, Guy P (2007) Development of the hair bundle and mechanotransduction. International Journal of Developmental Biology, 51 (6-7). pp. 597-608. ISSN 0214- 6282

Phillips, Kelli R, Tong, Song, Goodyear, Richard, Richardson, Guy P and Cyr, Janet L (2006) Stereociliary Myosin-1c Receptors Are Sensitive to Calcium Chelation and Absent from Cadherin 23 Mutant Mice. Journal of Neuroscience, 26 (42). pp. 10777-10788. ISSN 0270-6474

McGee, JoAnn, Goodyear, Richard J, McMillan, D Randy, Stauffer, Eric A, Holt, Jeffrey R, Locke, Kirsten G, Birch, David G, Legan, P Kevin, White, Perrin C, Walsh, Edward J and Richardson, Guy P (2006) The very large G-protein coupled receptor VLGR1: a component of the ankle link complex required for the normal development of auditory hair bundles. Journal of Neuroscience, 26 (24). pp. 6543-6553. ISSN 0270-6474

Ahmed, Zubair M, Goodyear, Richard, Riazuddin, Saima, Lagziel, Ayala, Legan, P Kevin, Behra, Martine, Burgess, Shawn M, Lilley, Kathryn S, Wilcox, Edward R, Riazuddin, Sheikh, Griffith, Andrew J, Frolenkov, Gregory I, Belyantseva, Inna A, Richardson, Guy P and Friedman, Thomas B (2006) The tip-link antigen, a protein associated with the transduction complex of sensory hair cells, is protocadherin-15. Journal of Neuroscience, 26 (26). pp. 7022-7034. ISSN 0270-6474

Legan, P Kevin, Lukashkina, Victoria A, Goodyear, Richard J, Lukashkin, Andrei N, Verhoeven, Kristien, Van Camp, Guy, Russell, Ian J and Richardson, Guy P (2005) A deafness mutation isolates a second role for the tectorial membrane in hearing. Nature Neuroscience, 8. pp. 1035-1042. ISSN 1097-6256

Leibovici, Michel, Verpy, Elisabeth, Goodyear, Richard J, Zwaenepoel, Ingrid, Blanchard, Stéphane, Lainé, Sophie, Richardson, Guy P and Petit, Christine (2005) Initial characterization of kinocilin, a protein of the hair cell kinocilium. Hearing Research, 203 (1-2). pp. 144-153. ISSN 0378-5955

Michel, Vincent, Goodyear, Richard J, Weil, Dominique, Marcotti, Walter, Perfettini, Isabelle, Wolfrum, Uwe, Kros, Corné J, Richardson, Guy P and Petit, Christine (2005) Cadherin 23 is a component of the transient lateral links in the developing hair bundles of cochlear sensory hair cells. Developmental Biology, 280 (2). pp. 281-294. ISSN 0012-1606

Delprat, Benjamin, Michel, Vincent, Goodyear, Richard, Yamasaki, Yasuhiro, Michalski, Nicolas, El-Amraoui, Aziz, Perfettini, Isabelle, Legrain, Pierre, Richardson, Guy, Hardelin, Jean-Pierre and Petit, Christine (2005) Myosin XVa and whirlin, two deafness gene products required for hair bundle growth, are located at the stereocilia tips and interact directly. Human Molecular Genetics, 14 (3). pp. 401-410. ISSN 0964-6906

Goodyear, Richard J, Marcotti, Walter, Kros, Corné J and Richardson, Guy P (2005) Development and properties of stereociliary link types in hair cells of the mouse cochlea. Journal of Comparative Neurology, 485 (1). 75 - 85. ISSN 0021-9967

Tsuprun, Vladimir, Goodyear, Richard J and Richardson, Guy P (2004) The Structure of Tip Links and Kinocilial Links in Avian Sensory Hair Bundles. Biophysical Journal, 87 (6). pp. 4106-4112. ISSN 0006-3495

Bashtanov, Mikhail E, Goodyear, Richard J, Richardson, Guy P and Russell, Ian J (2004) The mechanical properties of chick (Gallus domesticus) sensory hair bundles: relative contributions of structures sensitive to calcium chelation and subtilisin treatment. Journal of Physiology, 559 (1). pp. 287-299. ISSN 0022-3751

Ng, Lily, Goodyear, Richard J, Woods, Chad A, Schneider, Mark J, Diamond, Edward, Richardson, Guy P, Kelley, Matthew W, St Germain, Donald L, Galton, Valerie Anne and Forrest, Douglas (2004) Hearing loss and retarded cochlear development in mice lacking type 2 iodothyronine deiodinase. Proceedings of the National Academy of Sciences, 101 (10). pp. 3474-3479. ISSN 0027-8424

Goodyear, R J, Legan, P K, Wright, M B, Marcotti, W, Oganesian, A, Coats, S A, Booth, C J, Kros, C J, Seifert, R A, Bowen-Pope, D F and Richardson, G P (2003) A receptor-like inositol lipid phosphatase is required for the maturation of developing cochlear hair bundles. Journal of Neuroscience, 23 (27). pp. 9208-9219. ISSN 0270-6474

Amma, Lori L, Goodyear, Richard, Faris, Jonathan S, Jones, Iwan, Ng, Lily, Richardson, Guy and Forrest, Douglas (2003) An emilin family extracellular matris protein identified inthe cochlear basilar membrane. Molecular and Cellular Neuroscience, 23 (3). pp. 460-472. ISSN 1044-7431

Goodyear, Richard J and Richardson, Guy P (2003) A Novel Antigen Sensitive to Calcium Chelation That is Associated with the Tip Links and Kinocilial Links of Sensory Hair Bundles. Journal of Neuroscience, 23 (12). pp. 4878-4887. ISSN 0270-6474

Richardson, Guy, Goodyear, Richard, Legan, Kevin, Marcotti, Walter, Wright, M, Oganesian, A and Booth, C (2003) A receptor-like inositol lipid phosphatase required for the normal maturation of developing cochlear hair bundles. Journal of Neuroscience, 23 (27). pp. 9028-9219. ISSN 0270-6474

Boëda, Batiste, El-Amraoui, Aziz, Bahloul, Amel, Goodyear, Richard, Daviet, Laurent, Blanchard, Stéphane, Perfettini, Isabelle, Fath, Karl R, Shorte, Spencer, Reiners, Jan, Houdusse, Anne, Legrain, Pierre, Wolfrum, Uwe, Richardson, Guy and Petit, Christine (2002) Myosin VIIa, harmonin and cadherin23, three Usher I gene products cooperate to shape the sensory hair bundle. EMBO Journal, 21 (24). 6689 - 6699. ISSN 0261-4189

Goodyear, Richard J and Richardson, Guy P (2002) Extracellular matrices associated with the apical surfaces of sensory epithelia in the inner ear: Molecular and structural diversity. Journal of Neurobiology, 53 (2). pp. 212-227. ISSN 0022-3034

Zwaenepoel, Ingrid, Mustapha, Mirna, Leibovici, Michel, Verpy, Elisabeth, Goodyear, Richard, Liu, Xue Zhong, Nouaille, Sylvie, Nance, Walter E, Kanaan, Moien, Avraham, Karen B, Tekaia, Fredj, Loiselet, Jacques, Lathrop, Marc, Richardson, Guy and Petit, Christine (2002) Otoancorin, an inner ear protein restricted to the interface between the apical surface of sensory epithelia and their overlying acellular gels, is defective in autosomal recessive deafness DFNB22. Proceedings of the National Academy of Sciences, 99 (9). pp. 6240-6245. ISSN 0027-8424

Bryant, Jane, Goodyear, Richard J and Richardson, Guy P (2002) Sensory organ development in the inner ear: molecular and cellular mechanisms. British Medical Bulletin, 63. pp. 39-58.

Rüsch, Alfons, Ng, Lily, Goodyear, Richard, Oliver, Dominik, Lisoukov, Igor, Vennström, Björn, Richardson, Guy, Kelley, Matthew W and Forrest, Douglas (2001) Retardation of cochlear maturation and impaired hair cell function caused by deletion of all known thyroid hormone receptors. Journal of Neuroscience, 21 (24). pp. 9792-9800. ISSN 0270-6474

Knipper, Marlies, Richardson, Guy, Mack, Andreas, Müller, Markus, Goodyear, Richard, Limberger, Annette, Rohbock, Karin, Köpschall, Iris, Zenner, Hans-Peter and Zimmermann, Ulrike (2001) Thyroid hormone-deficient period prior to the onset of hearing is associated with reduced levels of beta-tectorin in the tectorial membrane: implication for hearing loss. Journal of Biological Chemistry, 276 (42). pp. 39046-39052. ISSN 0021-9258

Goodyear, Richard J, Kwan, Tao, Oh, Seung-Ha, Raphael, Yehoash and Richardson, Guy P (2001) The cell adhesion molecule BEN defines a prosensory patch in the developing avian otocyst. Journal of Comparative Neurology, 434 (3). pp. 275-288. ISSN 0021-9967

Legan, P Kevin, Lukashkina, Victoria A, Kössl, Manfred, Goodyear, Richard J, Russell, Ian J and Richardson, Guy P (2000) A targeted deletion in alpha-tectorin reveals that the tectorial membrane is required for the gain and timing of cochlear feedback. Neuron, 28 (1). pp. 273-285. ISSN 08966273

Kruger, Robert P, Goodyear, Richard J, Legan, P Kevin, Warchol, Mark E, Raphael, Yehoash, Cotanche, Douglas A and Richardson, Guy P (1999) The supporting-cell antigen: a receptor-like protein tyrosine phosphatase expressed in the sensory epithelia of the inner ear. Journal of Neuroscience, 19 (12). pp. 4815-4827. ISSN 0270-6474

Richardson, Guy and Goodyear, Richard (1999) The ankle-link antigen: an eiptope sensitive to calcium chelation associated with hair bundles and the calycal processes of photoreceptors. Journal of Neuroscience, 19 (10). pp. 3761-3772. ISSN 0270-6474

Coutinho, P, Goodyear, R, Legan, P K and Richardson, G P (1999) Chick a-tectorin: Molecular cloning and expression during embryogenesis. Hearing Research, 130 (1-2). pp. 62-74. ISSN 03785955

Legan, Kevin, Richardson, Guy, Kruger, Robert and Goodyear, Richard (1998) Identification and molecular cloning of proteins associated with the apical surfaces of hair and supporting cells. British Journal of Audiology, 32 (2). pag 123. ISSN 03005364

Coutinho, P, Goodyear, R, Legan, P K and Richardson, G P (1998) Molecular cloning of chick alpha-tectorin and its expression during embryogenesis. British Journal of Audiology, 32 (2). p. 72. ISSN 03005364

Goodyear, Richard and Richardson, Guy (1997) Pattern formation in the basilar papilla: evidence for cell rearrangement. Journal of Neuroscience, 17 (16). pp. 6289-6301. ISSN 02706474

Goodyear, R, Killick, R, Legan, P K and Richardson, G P (1996) Distribution of beta-tectorin mRNA in the early posthatch and developing avian inner ear. Hearing Research, 96 (1-2). pp. 167-78.

Book Section

Goodyear, Richard J, Kros, Corné J and Richardson, Guy P (2006) The development of hair cells in the inner ear. In: Eatock, Ruth Anne, Fay, Richard R and Popper, Arthur N (eds.) Vertebrate Hair Cells. Springer Verlag. ISBN 978-0-387-95202-4

Legan, P Kevin, Goodyear, Richard J, Van Camp, Guy and Richardson, Guy P (2004) Alpha-tectorin. In: Willems, Patrick J (ed.) Genetic Hearing Loss. Marcel Dekker Inc, pp. 291-306. ISBN 9780824743093