Article

Bano, Aalia, Pera Rojas, Alejandra, Almoukayed, Ahmad, Clarke, Thomas H S, Kirmani, Sukaina, Davies, Kevin A and Kern, Florian (2019) CD28null CD4 T-cell expansions in autoimmune disease suggest a link with cytomegalovirus infection. F1000Research. ISSN 2046-1402

Baraniak, Ilona, Kern, Florian, Holenya, Pavlo, Griffiths, Paul and Reeves, Matthew (2019) Original antigenic sin shapes the immunological repertoire evoked by HCMV gB-MF59 vaccine in seropositive recipients. The Journal of Infectious Diseases. ISSN 0022-1899

Jallad, Samer, Thoma, Philip, Newport, Melanie J and Kern, Florian (2018) Baseline cytokine profiles of tuberculin-specific CD4 T-cells in non-muscle invasive bladder cancer may predict outcomes of BCG immunotherapy within reach? Cancer Immunology Research, 6 (10). pp. 1212-1219. ISSN 2326-6066

Pera Rojas, Alejandra, Caserta, Stefano, Albanese, Fabio, Blowers, Pinar, Morrow, George, Terrazzini, Nadia, Smith, Helen E, Rajkumar, Chakravarthi, Reus, Bernhard, Msonda, James R, Verboom, Murielle, Hallenensleben, Michael, Blasczyk, Rainer, Davies, Kevin A and Kern, Florian (2018) CD28null pro-atherogenic CD4 T-cells explain the link between CMV infection and an increased risk of cardiovascular death. Theranostics, 8 (16). pp. 4509-4519. ISSN 1838-7640

Terrazzini, Nadia, Mantegani, Paola, Kern, Florian, Fortis, Claudio, Mondino, Anna and Caserta, Stefano (2018) IL-7 unveils pathogen-specific T cells by enhancing antigen-recall responses. Journal of Infectious Diseases, jiy096. ISSN 0022-1899

Caserta, Stefano, Mengozzi, Manuela, Kern, Florian, Newbury, Sarah F, Ghezzi, Pietro and Llewelyn, Martin J (2018) Severity of systemic inflammatory response syndrome (SIRS) affects the blood levels of circulating inflammatory-relevant miRNAs. Frontiers in Immunology, 9 (1977). ISSN 1664-3224

Bajwa Joseph, Martha, Vita, Serena, Vescovini, Rosana, Larsen, Martin, Sansoni, Paolo, Terrazzini, Nadia, Caserta, Stefano, Thomas, David, Davies, Kevin A, Smith, Helen and Kern, Florian (2017) CMV-specific T-cell responses at older ages: broad responses with a large central memory component may be key to long-term survival. Journal of Infectious Diseases, 215 (8). pp. 1212-1220. ISSN 0022-1899

Broadley, Iain, Pera, Alejandra, Morrow, George, Davies, Kevin and Kern, Florian (2017) Expansions of cytotoxic CD4+CD28− T-cells drive excess cardiovascular mortality in rheumatoid arthritis and other chronic inflammatory conditions and are triggered by CMV infection. Frontiers in Immunology, 8. a195. ISSN 1664-3224

Pera, Alejandra, Broadley, Iain, Davies, Kevin A and Kern, Florian (2017) Cytomegalovirus as a driver of excess cardiovascular mortality in rheumatoid arthritis: a red herring or a smoking gun? Circulation Research, 120 (2). pp. 274-277. ISSN 0009-7330

Bajwa Joseph, Martha, Vita, Serena, Vescovini, Rosanna, Larsen, Martin, Sansoni, Paolo, Terrazzini, Nadia, Caserta, Stefano, Thomas, David, Davies, Kevin A, Smith, Helen and Kern, Florian (2016) Functional diversity of CMV-specific T-cells is maintained in older people and significantly associated with protein specificity and response size. International Journal of Infectious Diseases, 214 (9). pp. 1430-1437. ISSN 1201-9712

Sylwester, Andrew, Nambiar, Kate Z, Caserta, Stefano, Klenerman, Paul, Picker, Louis J and Kern, Florian (2016) A new perspective of the structural complexity of HCMV-specific T-cell responses. Mechanisms of Ageing and Development, 158. pp. 14-22. ISSN 0047-6374

Bajwa, Martha, Vita, Serena, Vescovini, Rosanna, Larsen, Martin, Sansoni, Paolo, Terrazzini, Nadia, Caserta, Stefano, Thomas, David, Davies, Kevin, Smith, Helen and Kern, Florian (2016) Functional diversity of cytomegalovirus-specific T cells is maintained in older people and significantly associated with protein specificity and response size. Journal of Infectious Diseases, 214 (9). pp. 1430-1437. ISSN 0022-1899

Caserta, Stefano, Kern, Florian, Cohen, Jonathan, Drage, Stephen, Newbury, Sarah F and Llewelyn, Martin J (2016) Circulating plasma microRNAs can differentiate human sepsis and Systemic Inflammatory Response Syndrome (SIRS). Scientific Reports, 6. p. 28006. ISSN 2045-2322

Chiu, Yen-Ling, Lin, Chung-Hao, Sung, Bo-Yi, Chuang, Yi-Fang, Schneck, Jonathan P, Kern, Florian, Pawelec, Graham and Wang, George C (2016) Cytotoxic polyfunctionality maturation of cytomegalovirus-pp65-specific CD4 + and CD8 + T-cell responses in older adults positively correlates with response size. Scientific Reports, 6. p. 19227. ISSN 2045-2322

Terrazzini, Nadia, Bajwa Joseph, Martha, Vita, Serena, Thomas, David, Smith, Helen, Vescovini, Rosanna, Sansoni, Paolo and Kern, Florian (2014) Cytomegalovirus infection modulates the phenotype and functional profile of the T-cell immune response to mycobacterial antigens in older life. Experimental Gerontology, 54. pp. 94-100. ISSN 05315565

Terrazzini, Nadia and Kern, Florian (2014) Cell-mediated immunity to human CMV infection: a brief overview. F1000prime reports, 6. p. 28. ISSN 2051-7599

Anderson, Suzanne T, Kaforou, Myrsini, Brent, Andrew J, Wright, Victoria J, Banwell, Claire M, Chagaluka, George, Crampin, Amelia C, Dockrell, Hazel M, French, Neil, Hamilton, Melissa S, Hibberd, Martin L, Kern, Florian, Langford, Paul R, Ling, Ling, Mlotha, Rachel, Ottenhoff, Tom H M, Pienaar, Sandy, Pillay, Vashini, Scott, J Anthony G, Twahir, Hemed, Wilkinson, Robert J, Coin, Lachlan J, Heyderman, Robert S, Levin, Michael and Eley, Brian (2014) Diagnosis of childhood tuberculosis and host RNA expression in Africa. New England Journal of Medicine, 370 (18). pp. 1712-1723. ISSN 0028-4793

Terrazzini, Nadia, Bajwa Joseph, Martha, Vita, Serena, Cheek, Elizabeth, Thomas, David, Seddiki, Nabila, Smith, Helen and Kern, Florian (2014) A novel cytomegalovirus-induced regulatory-type t-cell subset increases in size during older life and links virus-specific immunity to vascular pathology. Journal of Infectious Diseases, 209 (9). pp. 1382-1392. ISSN 0022-1899

Smith, Karen A, Gray, Nicola J, Saleh, Femi, Cheek, Elizabeth, Frew, Anthony J, Kern, Florian and Tarzi, Michael D (2013) Characterisation of CD154+ T cells following ex vivo allergen stimulation illustrates distinct T cell responses to seasonal and perennial allergens in allergic and non-allergic individuals. BMC Immunology, 14 (1). ISSN 1471-2172

Cattamanchi, Adithya, Kaforou, Myrsini, Wright, Victoria J, Oni, Tolu, French, Neil, Anderson, Suzanne T, Bangani, Nonzwakazi, Banwell, Claire M, Brent, Andrew J, Crampin, Amelia C, Dockrell, Hazel M, Eley, Brian, Heyderman, Robert S, Hibberd, Martin L, Kern, Florian, Langford, Paul R, Ling, Ling, Mendelson, Marc, Ottenhoff, Tom H, Zgambo, Femia, Wilkinson, Robert J, Coin, Lachlan J and Levin, Michael (2013) Detection of tuberculosis in HIV-infected and - uninfected African adults using whole blood RNA expression signatures: a case-control study. PLoS Medicine, 10 (10). e1001538. ISSN 1549-1676

Smith, Karen A, Gray, Nicola J, Cheek, Elizabeth, Saleh, Femi, Lavender, Jo, Frew, Anthony J, Kern, Florian and Tarzi, Michael (2013) Characterisation of CD154+ T cells following ex vivo birch allergen stimulation defines a close relationship between T cell subsets in healthy volunteers. BMC Immunology, 14 (14). pp. 1-11. ISSN 1471-2172

Lanuti, Paola, Ciccocioppo, Fausta, Bonanni, Laura, Marchisio, Marco, Lachmann, Raskit, Tabet, Naji, Pierdomenico, Laura, Santavenere, Eugenio, Catinella, Virginia, Iacone, Antonio, Thomas, Astrid, Gambi, Domenico, Miscia, Sebastiano, Onofrj, Marco and Kern, Florian (2012) Amyloid-specific T-cells differentiate Alzheimer's disease from Lewy body dementia. Neurobiology of Aging, 33 (11). pp. 2599-2611. ISSN 0197-4580

Streitz, M, Fuhrmann, S, Thomas, D, Cheek, E, Nomura, L, Maecker, H, Martus, P, Aghaeepour, N, Brinkman, R R, Volk, H D and Kern, F (2012) The phenotypic distribution and functional profile of tuberculin-specific CD4 T-cells characterizes different stages of TB infection. Cytometry. Part B : Clinical Cytometry. ISSN 1552-4949

Fuhrmann, S, Lachmann, R, Streitz, M, Hetzer, R, Volk, H D, Lehmkuhl, H and Kern, F (2012) Cyclosporin A and tacrolimus reduce T-cell polyfunctionality but not interferon-gamma responses directed at cytomegalovirus. Immunology, 136 (4). pp. 408-413. ISSN 0019-2805

Lachmann, Raskit, Bajwa, Martha, Vita, Serena, Smith, Helen, Cheek, Elizabeth, Akbar, Arne and Kern, Florian (2012) Polyfunctional T cells accumulate in large human Cytomegalovirus-specific T cell responses. Journal of Virology, 86 (2). pp. 1001-1009. ISSN 0022-538X

Lachman, R, Bajwa, M, Vita, S, Smith, H, Cheek, E, Akbar, A and Kern, F (2012) Polyfunctional T cells accumulate in large human cytomegalovirus-specific T cell responses. Journal of Virology, 86 (2). pp. 1001-1009. ISSN 0022-538X

Carbone, J, Lanio, N, Gallego, A, Kern, F, Navarro, J, Munoz, P, Alonso, R, Catalan, P, Fernandez-Yanez, J, Palomo, J, Ruiz, M, Fernandez-Cruz, E and Sarmiento, E (2012) Simultaneous monitoring of cytomegalovirus-specific antibody and T-cell levels in seropositive heart transplant recipients. Journal of Clinical Immunology, 32 (4). pp. 809-19. ISSN 0271-9142

Wang, Y, Sun, B, Volk, H D, Proesch, S and Kern, F (2011) Comparative study of the influence of proteasome inhibitor MG132 and ganciclovir on the cytomegalovirus-specific CD8(+) T-cell immune response. Viral Immunology, 24 (6). pp. 455-461. ISSN 0882-8245

Wills, M, Akbar, A, Beswick, M, Bosch, J A, Caruso, C, Colonna-Romano, G, Dutta, A, Franceschi, C, Fulop, T, Gkrania-Klotsas, E, Goronzy, J, Griffiths, S J, Henson, S, Herndler-Brandstetter, D, Hill, A, Kern, F, Klenerman, P, Macallan, D, Macualay, R, Maier, A B, Mason, G, Melzer, D, Morgan, M, Moss, P, Nikolich-Zugich, J, Pachnio, A, Riddell, N, Roberts, R, Sansoni, P, Sauce, D, Sinclair, J, Solana, R, Strindhall, J, Trzonkowski, P, van Lier, R, Vescovini, R, Wang, G, Westendorp, R and Pawelec, G (2011) Report from the second cytomegalovirus and immunosenescence workshop. Immunity and Ageing, 8 (1). p. 10. ISSN 1742-4933

Weitz, M, Kiessling, C, Friedrich, M, Prosch, S, Hoflich, C, Kern, F, Volk, H D, Sterry, W, Asadullah, K and Docke, W D (2011) Persistent CMV infection correlates with disease activity and dominates the phenotype of peripheral CD8+ T cells in psoriasis. Experimental Dermatology, 20 (7). pp. 561-567. ISSN 0906-6705

Libri, Valentina, Azevedo, Rita I., Jackson, Sarah E., Di Mitri, Diletta, Lachmann, Raskit, Fuhrmann, Stephan, Vukmanovic-Stejic, Milica, Yong, Kwee, Battistini, Luca, Kern, Florian, Soares, Maria V. D. and Akbar, Arne N. (2011) Cytomegalovirus infection induces the accumulation of short-lived, multifunctional CD4(+) CD45RA(+) CD27(-) T cells: the potential involvement of interleukin-7 in this process. Immunology, 132 (3). pp. 326-339. ISSN 0019-2805

Libri, V, Azevedo, R I, Jackson, S E, Di Mitri, D, Lachmann, R, Fuhrmann, S, Vukmanovic-Stejic, M, Yong, K, Battistini, L, Kern, F, Soares, M V and Akbar, A N (2011) Cytomegalovirus infection induces the accumulation of short-lived, multifunctional CD4+CD45RA+CD27+ T cells: the potential involvement of interleukin-7 in this process. Immunology, 132 (3). pp. 326-339. ISSN 0019-2805

Streitz, Mathias, Fuhrmann, Stephan, Powell, Fiona, Quassem, Ali, Nomura, Laurel, Maecker, Holden, Martus, Peter, Volk, Hans-Dieter and Kern, Florian (2011) Tuberculin-Specific T Cells Are Reduced in Active Pulmonary Tuberculosis Compared to LTBI or Status Post BCG Vaccination. Journal of Infectious Diseases, 203 (3). pp. 378-382. ISSN 0022-1899

Streitz, M, Fuhrmann, S, Powell, F, Quassem, A, Nomura, L, Maecker, H, Martus, P, Volk, H D and Kern, F (2011) Tuberculin-specific T cells are reduced in active pulmonary tuberculosis compared to LTBI or status post BCG vaccination. Journal of Infectious Diseases, 203 (3). pp. 378-382. ISSN 0022-1899

Pawelec, G, Akbar, A, Beverley, P, Caruso, C, Derhovanessian, E, Fulop, T, Griffiths, P, Grubeck-Loebenstein, B, Hamprecht, K, Jahn, G, Kern, F, Koch, S D, Larbi, A, Maier, A B, Macallan, D, Moss, P, Samson, S, Strindhall, J, Trannoy, E and Wills, M (2010) Immunosenescence and Cytomegalovirus: where do we stand after a decade? Immunity and Ageing, 7. p. 13. ISSN 1742-4933

Bunk, S, Schaffert, H, Schmid, B, Goletz, C, Zeller, S, Borisova, M, Kern, F, Rupp, J and Hermann, C (2010) Chlamydia pneumoniae-induced memory CD4+ T-cell activation in human peripheral blood correlates with distinct antibody response patterns. Clinical and Vaccine Immunology, 17 (5). pp. 705-712. ISSN 1556-679X

Sierra, B, Perez, A B, Vogt, K, Garcia, G, Schmolke, K, Aguirre, E, Alvarez, M, Kern, F, Kouri, G, Volk, H D and Guzman, M G (2010) Secondary heterologous dengue infection risk: Disequilibrium between immune regulation and inflammation? Cellular Immunology, 262 (2). pp. 134-140. ISSN 0008-8749

Lanuti, P, Fuhrmann, S, Lachmann, R, Marchisio, M, Miscia, S and Kern, F (2009) Simultaneous characterization of phospho-proteins and cell cycle in activated T cell subsets. International Journal of Immunopathology and Pharmacology, 22 (3). pp. 689-698. ISSN 0394-6320

Nickel, P, Bold, G, Presber, F, Biti, D, Babel, N, Kreutzer, S, Pratschke, J, Schonemann, C, Kern, F, Volk, H D and Reinke, P (2009) High levels of CMV-IE-1-specific memory T cells are associated with less alloimmunity and improved renal allograft function. Transplant Immunology, 20 (4). pp. 238-242. ISSN 0966-3274

Fuhrmann, S, Streitz, M and Kern, Florian (2008) How flow cytometry is changing the study of TB immunology and clinical diagnosis. Cytometry. Part A, 73 (11). pp. 1100-1106. ISSN 1552-4922

Gratama, J W, Kern, F, Manca, F and Roederer, M (2008) Measuring antigen-specific immune responses, 2008 update. Cytometry. Part A, 73 (11). pp. 971-974. ISSN 1552-4922

Kirchner, A, Hoffmeister, B, Cherepnev-G, G, Fuhrmann, S, Streitz, M, Lachmann, R, Bunde, T, Meij, P, Schonemann, C, Hetzer, R, Lehmkuhl, H B, Volkmer-Engert, R, Volk, H D, Gratama, J W and Kern, F (2008) Dissection of the CMV specific T-cell response is required for optimized cardiac transplant monitoring. Journal of Medical Virology, 80 (9). pp. 1604-1614. ISSN 0146-6615

Streitz, Mathias, Noutsias, Michel, Volkmer, Rudolf, Rohde, Maria, Brestrich, Gordon, Block, Andrea, Klippert, Katrin, Kotsch, Katja, Ay, Bernhard, Hummel, Michael, Kuehl, Uwe, Lassner, Dirk, Schultheiss, Heinz-Peter, Volk, Hans-Dieter and Kern, Florian (2008) NS1 Specific CD8(+) T-Cells with Effector Function and TRBV11 Dominance in a Patient with Parvovirus B19 Associated Inflammatory Cardiomyopathy. PLoS ONE, 3 (6). e2361. ISSN 1932-6203

Streitz, M, Noutsias, M, Volkmer, R, Rohde, M, Brestrich, G, Block, A, Klippert, K, Kotsch, K, Ay, B, Hummel, M, Kuhl, U, Lassner, D, Schultheiss, H P, Volk, H D and Kern, F (2008) NS1 specific CD8+ T-cells with effector function and TRBV11 dominance in a patient with parvovirus B19 associated inflammatory cardiomyopathy. PLoS ONE, 3 (6). e2361. ISSN 1932-6203

Fuhrmann, Stephan, Streitz, Mathias, Reinke, Petra, Volk, Hans-Dieter and Kern, Florian (2008) T cell response to the cytomegalovirus major capsid protein (UL86) is dominated by helper cells with a large polyfunctional component and diverse epitope recognition. Journal of Infectious Diseases, 197 (10). pp. 1455-1458. ISSN 0022-1899

Fuhrmann, S, Streitz, M, Reinke, P, Volk, H D and Kern, F (2008) T cell response to the cytomegalovirus major capsid protein (UL86) is dominated by helper cells with a large polyfunctional component and diverse epitope recognition. Journal of Infectious Diseases, 197 (10). pp. 1455-1458. ISSN 0022-1899

Janossy, George, Barry, Simon M, Breen, Ronan A M, Hardy, Gareth A D, Lipman, Marc and Kern, Florian (2008) The role of flow cytometry in the interferon-gamma-based diagnosis of active tuberculosis and its coinfection with HIV-1--A technically oriented review. Cytometry Part B: Clinical Cytometry, 74b (S1). S141-151. ISSN 1552-4949

Letsch, A, Knoedler, M, Na, I K, Kern, F, Asemissen, A M, Keilholz, U, Loesch, M, Thiel, E, Volk, H D and Scheibenbogen, C (2007) CMV-specific central memory T cells reside in bone marrow. European Journal of Immunology, 37 (11). pp. 3063-3068. ISSN 0014-2980

Streitz, M, Tesfa, L, Yildirim, V, Yahyazadeh, A, Ulrichs, T, Lenkei, R, Quassem, A, Liebetrau, G, Nomura, L, Maecker, H, Volk, H D and Kern, F (2007) Loss of receptor on tuberculin-reactive T-cells marks active pulmonary tuberculosis. PLoS ONE, 2 (8). e735. ISSN 1932-6203

Ay, Bernhard, Streitz, Mathias, Boisguerin, Prisca, Schlosser, Andreas, Mahrenholz, Carsten C., Schuck, Sebastian D., Kern, Florian and Volkmer, Rudolf (2007) Sorting and pooling strategy: a novel tool to map a virus proteome for CD8 T-cell epitopes. Biopolymers, 88 (1). pp. 64-75. ISSN 0006-3525 (Print) 0006-3525 (Linking)

Book Section

Pera, Alejandra, Bano, Aalia and Kern, Florian (2018) Role of cytomegalovirus in driving cytotoxic CD28null T cells. In: Handbook of Immunosenescence. Springer, Cham, pp. 1-19. ISBN 9783319645971

Scheffold, Alexander, Bacher, Petra and Kern, Florian (2015) Durchflusszytometrische analysen zur detektion antigenspezifischer T-Zellen. In: Sack, Ulrich (ed.) Zelluläre diagnostik und therapie. De Gruyter, Germany, pp. 82-99. ISBN 9783110344066

Conference or Workshop Item

Rajkumar, Chakravarthi, Davies, Kevin and Kern, Florian (2017) Does arterial ageing differ between Europeans and Japanese and Korean patient samples? Results from current UK studies. In: ARTERY 2017, 12-14 October 2017, Pisa, Italy.

Rajkumar, Chakravarthi, Davies, Kevin and Kern, Florian (2017) Are you really as old as your arteries: predicting biological age using the Cardio-Ankle Vascular Index as a marker of vascular stiffness. In: British Geriatric Society Cardiovascular section, 6th October 2017, London.

Caserta, Stefano, Kern, Florian, Cohen, Jonathan, Drage, Stephen, Newbury, Sarah and Llewelyn, Martin (2015) Circulating miRNA in critical inflammatory conditions. In: 4th European Congress of Immunology - Vienna 2015, 6-9 September 2015, Vienna, Austria.

Terrazzini, Nadia, Morrow, George, Kern, Florian and Caserta, Stefano (2015) IL-7 enhances the responsiveness of CMV effectors. In: 4th European Congress of Immunology - Vienna 2015, 6-9 September 2015, Vienna, Austria.

Morrow, G, Caserta, S, Terrazzini, N, Smith, H, Rajkumar, C and Kern, F (2014) The role of CMV-specific immunity in the association between CMV infection and vascular complications in older age. In: British Society of Immunology 2014, 1-4 December 2014, Brighton, UK.