Article

Sansook, Supojjanee, Lineham, Ella, Hassell-Hart, Storm, Tizzard, Graham J, Coles, Simon J, Spencer, John and Morley, Simon J (2018) Probing the anticancer action of novel ferrocene analogues of MNK inhibitors. Molecules, 23 (2126). pp. 1-13. ISSN 1420-3049

Lineham, Ella, Tizzard, Graham J, Coles, Simon J, Spencer, John and Morley, Simon (2018) Synergistic effects of inhibiting the MNK-eIF4E and PI3K/AKT/mTOR pathways on cell migration in MDA-MB-231 cells. Oncotarget. ISSN 1949-2553

Lineham, Ella, Spencer, John and Morley, Simon (2017) Dual abrogation of Mnk and mTOR; a novel therapeutic approach for the treatment of aggressive cancers. Future Medicinal Chemistry, 9 (13). ISSN 1756-8919

Copsey, Alice C, Cooper, Simon, Parker, Robert, Lineham, Ella, Lapworth, Cuzack, JALLAD, Deema Basil Sadiq, Sweet, Steve and Morley, Simon J (2017) The helicase, DDX3X, interacts with poly(A) binding protein 1 (PABP1) and caprin-1 at the leading edge of migrating fibroblasts and is required for efficient cell spreading. Biochemical Journal, 474 (18). pp. 3109-3120. ISSN 0264-6021

Jongjitwimol, Jirapas, Baldock, Robert A, Morley, Simon J and Watts, Felicity Z (2016) Sumoylation of eIF4A2 affects stress granule formation. Journal of Cell Science, 129 (12). pp. 2407-2415. ISSN 0021-9533

Royall, Elizabeth, Doyle, Nicole, Abdul-Wahab, Azimah, Emmott, Ed, Morley, Simon J, Goodfellow, Ian, Roberts, Lisa O and Locker, Nicolas (2015) Murine norovirus 1 (MNV1) replication induces translational control of the host by regulating eIF4E activity during infection. Journal of Biological Chemistry, 290 (8). pp. 4748-58. ISSN 0021-9258

Pollard, Hilary J, Willett, Mark and Morley, Simon J (2014) mTOR kinase-dependent, but raptor-independent regulation of downstream signaling is important for cell cycle exit and myogenic differentiation. Cell Cycle, 13 (16). pp. 2517-2525. ISSN 1538-4101

Jongjitwimol, Jirapas, Feng, Min, Zhou, Lihong, Wilkinson, Oliver, Small, Lauren, Baldock, Robert, Taylor, Deborah L, Smith, Duncan, Bowler, Lucas, Morley, Simon J and Watts, Felicity (2014) The S. pombe translation initiation factor eIF4G is sumoylated and associates with the SUMO protease Ulp2. PLoS ONE, 9 (5). e94182. ISSN 1932-6203

Smalley, Sarah, Chalmers, Anthony J and Morley, Simon J (2014) mTOR inhibition and levels of the DNA repair protein MGMT in T98G glioblastoma cells. Molecular Cancer, 13 (1). p. 144. ISSN 1476-4598

Coldwell, Mark J, Cowan, Joanne L, Vlasak, Markete, Mead, Abbie, Willett, Mark, Perry, Lisa S and Morley, Simon J (2013) Phosphorylation of eIF4GII and 4E-BP1 in response to nocodazole treatment: a reappraisal of translation initiation during mitosis. Cell Cycle, 12 (23). pp. 3615-3628. ISSN 1538-4101

Clemens, Michael J, Elia, Androulla and Morley, Simon J (2013) Requirement for the eIF4E binding proteins for the synergistic down-regulation of protein synthesis by hypertonic conditions and mTOR inhibition. PLoS ONE, 8 (8). e71138. ISSN 1932-6203

Willett, Mark, Brocard, Michele, Pollard, Hilary J and Morley, Simon J (2013) mRNA encoding WAVE-Arp2/3-associated proteins is co-localized with foci of active protein synthesis at the leading edge of MRC5 fibroblasts during cell migration. The Biochemical Journal, 452 (1). pp. 45-55. ISSN 1470-8728

Coldwell, Mark J, Sack, Ulrike, Cowan, Joanne L, Barrett, Rachel M, Vlasak, Markete, Sivakumaran, Keiley and Morley, Simon J (2012) Multiple isoforms of the translation initiation factor eIF4GII are generated via use of alternative promoters, splice sites and a non-canonical initiation codon. Biochemical Journal, 448 (1). pp. 1-11. ISSN 0264-6021

González-Estévez, Cristina, Felix, Daniel A, Smith, Matthew D, Paps, Jordi, Morley, Simon J, James, Victoria, Sharp, Tyson V and Aboobaker, A Aziz (2012) SMG-1 and mTORC1 act antagonistically to regulate response to injury and growth in planarians. PLoS Genetics, 8 (3). e1002619. ISSN 1553-7390

Vosler, Peter S, Gao, Yanqin, Brennan, Christopher S, Yanagiya, Akiko, Gan, Yu, Cao, Guodong, Zhang, Feng, Morley, Simon J, Sonenberg, Nahum, Bennett, Michael V L and Chen, Jun (2011) Ischemia-induced calpain activation causes eukaryotic (translation) initiation factor 4G1 (eIF4GI) degradation, protein synthesis inhibition, and neuronal death. Proceedings of the National Academy of Sciences, 108 (44). pp. 18102-18107. ISSN 1091-6490

Morley, Simon, Brocard, Michele, Davide, Alexandre and Willett, Mark (2011) Translation initiation factors and active sites of protein synthesis co-localise at the leading edge of migrating MRC5 fibroblasts. Biochemical Journal, 438 (1). pp. 217-227. ISSN 0264-6021

Willett, Mark, Brocard, Michele, Davide, Alexandre and Morley, Simon J (2011) Translation initiation factors and active sites of protein synthesis co-localize at the leading edge of migrating fibroblasts. The Biochemical Journal, 438 (1). pp. 217-227. ISSN 1470-8728

Bhatia, Payal, Menigatti, Mirco, Brocard, Michele, Morley, Simon J and Ferrari, Stefano (2010) Mitotic DNA damage targets the Aurora A/TPX2 complex. Cell Cycle, 9 (22). pp. 4592-4599. ISSN 1538-4101

James, Victoria, Zhang, Yining, Foxler, Daniel E, de Moor, Cornelia H, Kong, Yi Wen, Webb, Thomas M, Self, Tim J, Feng, Yungfeng, Lagos, Dimitrios, Chu, Chia-Ying, Rana, Tariq M, Morley, Simon J, Longmore, Gregory D, Bushell, Martin and Sharp, Tyson V (2010) LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing. Proceedings of the National Academy of Sciences, 107 (28). pp. 12499-12504. ISSN 0027-8424

Willett, Mark, Pollard, Hilary J, Vlasak, Marketa and Morley, Simon J (2010) Localization of ribosomes and translation initiation factors to talin/beta3-integrin-enriched adhesion complexes in spreading and migrating mammalian cells. Biology of the Cell, 102 (5). pp. 265-276. ISSN 0248-4900

Willett, Mark, Cowan, Joanne L, Vlasak, Markete, Coldwell, Mark J and Morley, Simon J (2009) Inhibition of mammalian target of rapamycin (mTOR) signalling in C2C12 myoblasts prevents myogenic differentiation without affecting the hyperphosphorylation of 4E-BP1. Cellular Signalling, 21 (10). pp. 1504-1512. ISSN 0898-6568

Morley, Simon J and Willett, Mark (2009) Kinky Binding and SECsy Insertions. Molecular Cell, 35 (4). pp. 396-398. ISSN 1097-2765

Spriggs, Keith A, Cobbold, Laura C, Jopling, Catherine L, Cooper, Rebecca E, Wilson, Lindsay A, Stoneley, Mark, Coldwell, Mark J, Poncet, Didier, Shen, Ya-Ching, Morley, Simon, Bushell, Martin and Willis, Anne E (2009) Canonical initiation factor requirements of the Myc family of internal ribosome entry segments. Molecular and Cellular Biology, 29 (6). pp. 1565-1574. ISSN 0270-7306

Morley, Simon J and Willett, Mark (2008) Signaling Pathways Open the GAITway to Translational Control. Developmental Cell, 15 (5). pp. 639-640. ISSN 1534-5807

Morley, Simon J and Coldwell, Mark J (2008) A Cunning Stunt: An Alternative Mechanism of Eukaryotic Translation Initiation. Science Signaling, 1 (25). ISSN 1945-0877

Wheatley, Sally P, Barrett, Rachel M, Andrews, Paul D, Medema, Rene H, Morley, Simon J, Swedlow, Jason R and Lens, Susanne M A (2007) Phosphorylation by aurora-B negatively regulates survivin function during mitosis. Cell Cycle, 6 (10). pp. 1220-1230. ISSN 1538-4101

Morley, S and Cook, S (2007) Nutrient-responsive mTOR signalling grows on sterile ground. Biochemical Journal, 403 (1). e1-e3. ISSN 0264-6021

Hinton, Tracey M, Coldwell, Mark J, Carpenter, Gillian A, Morley, Simon J and Pain, Virginia M (2007) Functional Analysis of Individual Binding Activities of the Scaffold Protein eIF4G. Journal of Biological Chemistry, 282 (3). pp. 1695-1708. ISSN 0021-9258

Coldwell, Mark J and Morley, Simon J (2006) Specific isoforms of translation initiation factor 4GI show differences in translational activity. Molecular and Cellular Biology, 26 (22). pp. 8448-8460. ISSN 0270-7306

Willett, M, Flint, S A, Morley, S J and Pain, V M (2006) Compartmentalisation and localisation of the translation initiation factor (eIF) 4F complex in normally growing fibroblasts. Experimental Cell Research, 312 (15). pp. 2942-2953. ISSN 0014-4827

Willett, Mark, Flint, Simon A, Morley, Simon J and Pain, Virginia M (2006) Compartmentalisation and localisation of the translation initiation factor (eIF) 4F complex in normally growing fibroblasts. Experimental Cell Research, 312 (15). pp. 2942-2953. ISSN 0014-4827

DeGracia, D J, Rafols, J A, Morley, S J and Kayali, F (2006) Immunohistochemical mapping of total and phosphorylated eukaryotic initiation factor 4G in rat hippocampus following global brain ischemia and reperfusion. Neuroscience, 139 (4). pp. 1235-1248. ISSN 0306-4522

Coldwell, M. J. and Morley, S. J. (2006) Specific isoforms of translation initiation factor 4GI show differences in translational activity. Molecular and Cellular Biology, 26 (22). pp. 8448-8460. ISSN 0270-7306

Ling, Jun, Morley, Simon J and Traugh, Jolinda A (2005) Inhibition of cap-dependent translation via phosphorylation of eIF4G by protein kinase Pak2. EMBO Journal, 24 (23). pp. 4094-4105. ISSN 0261-4189

Morley, S J, Coldwell, M J and Clemens, M J (2005) Initiation factor modifications in the preapoptotic phase. Cell Death & Differentiation, 12. pp. 571-584. ISSN 1350-9047

Thorpe, Julian R, Mosaheb, Sabrina, Hashemzadeh-Bonehi, Lida, Cairns, Nigel J, Kay, John E, Morley, Simon J and Rulten, Stuart L (2004) Shortfalls in the Peptidyl-Prolyl Cis-Trans Isomerase Protein Pin 1 in Neurons are Associated with Frontotemporal Dementias. Neurobiology of Disease, 17 (2). pp. 237-249. ISSN 0969-9961

Thorpe, JR, Mosaheb, S, Hashemzadeh-Bonehi, L, Cairns, NJ, Kay, JE, Morley, SJ and Rulten, SL (2004) Shortfalls in the peptidyl-prolyl cis-trans isomerase protein Pin1 in neurons are associated with frontotemporal dementias. Neurobiology of Disease, 17 (2). pp. 237-249. ISSN 0969-9961

Cowan, Joanne L and Morley, Simon J (2004) The proteasome inhibitor, MG132, promotes the reprogramming of translation in C2C12 myoblasts and facilitates the association of hsp25 with the eIF4F complex. FEBS Journal, 271 (17). pp. 3596-3611. ISSN 1742-464X

Medina-Palazon, Cahora, Bernard, Emmanuelle, Frost, Victoria, Morley, Simon and Sinclair, Alison J. (2004) KIPase activity is a novel caspase-like activity associated with cell proliferation. FEBS Journal, 271 (13). pp. 2716-2723. ISSN 1742-464X

Naegele, Susanne and Morley, Simon J (2004) Molecular Cross-talk between MEK1/2 and mTOR Signaling during Recovery of 293 Cells from Hypertonic Stress. Journal of Biological Chemistry, 279 (44). pp. 46023-46034. ISSN 0021-9258

Coldwell, Mark J, Hashemzadeh-Bonehi, Lida, Hinton, Tracey M, Morley, Simon J and Pain, Virginia M (2004) Expression of fragments of translation initiation factor eIF4GI reveals a nuclear localisation signal within the N-terminal apoptotic cleavage fragment N-FAG. Journal of Cell Science, 117. pp. 2545-2555. ISSN 0021-9533

Morley, Simon J and Naegele, Susanne (2003) Phosphorylation of initiation factor 4E is resistant to SB203580 in cells expressing a drug-resistant mutant of stress-activated protein kinase 2a/p38. Cellular Signalling, 15 (8). pp. 741-749. ISSN 0898-6568

Walsh, Derek, Meleady, Paula, Power, Brendan, Morley, Simon J and Clynes, Martin (2003) Increased levels of the translation initiation factor eIF4E in differentiating epithelial lung tumor cell lines. Differentiation, 71 (2). pp. 126-134. ISSN 0301-4681

Hashemzadeh-Bonehi, Lida, Curtis, Penelope S, Morley, Simon J, Thorpe, Julian R and Pain, Virginia M (2003) Overproduction of a conserved domain of fission yeast and mammalian translation initiation factor eIF4G causes aberrant cell morphology and results in disruption of the localization of F-actin and the organization of microtubules. Genes to Cells, 8 (2). pp. 163-178. ISSN 1356-9597

Ling, Jun, Morley, Simon J, Pain, Virginia M, Marzluff, William F and Gallie, Daniel R (2002) The Histone 3'-Terminal Stem-Loop-Binding Protein Enhances Translation through a Functional and Physical Interaction with Eukaryotic Initiation Factor 4G (eIF4G) and eIF3. Molecular and Cellular Biology, 22 (22). pp. 7853-7867. ISSN 0270-7306

Ohlmann, Théophile, Prévôt, Déborah, Décimo, Didier, Roux, Florence, Garin, Jérôme, Morley, Simon J and Darlix, Jean-Luc (2002) In Vitro Cleavage of eIF4GI but not eIF4GII by HIV-1 Protease and its Effects on Translation in the Rabbit Reticulocyte Lysate System. Journal of Molecular Biology, 318 (1). pp. 9-20. ISSN 0022-2836

Morley, Simon J and Naegele, Susanne (2002) Phosphorylation of eukaryotic initiation factor (eIF) 4E is not required for de novo protein synthesis following recovery from hypertonic stress in human kidney cells. Journal of Biological Chemistry, 277 (36). pp. 32855-32859. ISSN 0021-9258

Jeffrey, Ian W, Bushell, Martin, Tilleray, Vivienne J, Morley, Simon and Clemens, Michael J (2002) Inhibition of protein synthesis in apoptosis: differential requirements by the tumor necrosis factor alpha family and a DNA-damaging agent for caspases and the double-stranded RNA-dependent protein kinase. Cancer Research, 62 (8). pp. 2272-2280. ISSN 0008-5472

McKendrick, Linda, Morley, Simon J, Pain, Virginia M, Jagus, Rosemary and Joshi, Bhavesh (2001) Phosphorylation of eukaryotic initiation factor 4E (eIF4E) at Ser209 is not required for protein synthesis in vitro and in vivo. European Journal of Biochemistry, 268 (20). pp. 5375-5385. ISSN 0014-2956

Ali, Iraj K, McKendrick, Linda, Morley, Simon J and Jackson, Richard J (2001) Activity of the Hepatitis A Virus IRES Requires Association between the Cap-Binding Translation Initiation Factor (eIF4E) and eIF4G. Journal of Virology, 75 (17). pp. 7854-7863. ISSN 0022-538X

Morley, Simon J and Pain, Virginia M (2001) Proteasome inhibitors and immunosuppressive drugs promote the cleavage of eIF4GI and eIF4GII by caspase-8-independent mechanisms in Jurkat T cell lines. FEBS Letters, 503 (2-3). pp. 206-212. ISSN 0014-5793

Ali, Iraj K, McKendrick, Linda, Morley, Simon J and Jackson, Richard J (2001) Truncated initiation factor eIF4G lacking an eIF4E binding site can support capped mRNA translation. EMBO Journal, 20 (15). pp. 4233-4242. ISSN 0261-4189

Bushell, Martin, Wood, Wendy, Carpenter, Gillian, Pain, Virginia M, Morley, Simon J and Clemens, Michael J (2001) Disruption of the interaction of mammalian protein synthesis eukaryotic initiation factor 4B with the poly(A)-binding protein by caspase- and viral-mediated proteases. Journal of Biological Chemistry, 276 (26). pp. 23922-23928. ISSN 0021-9258

Thorpe, Julian R, Morley, Simon J and Rulten, Stuart L (2001) Utilizing the Peptidyl-Prolyl Cis-Trans Isomerase Pin 1 as a Probe of its Phosphorylated Target Proteins: Examples of Binding to Nuclear Proteins in a Human Kidney Cell Line and to Tau in Alzheimer's Diseased Brain. Journal of Histochemistry and Cytochemistry, 49 (1). pp. 97-108. ISSN 0022-1554

McKendrick, Linda, Thompson, Elizabeth, Ferreira, Joao, Morley, Simon J and Lewis, Joe D (2001) Interaction of eukaryotic translation initiation factor 4G with the nuclear cap-binding complex provides a link between nuclear and cytoplasmic functions of the m7 guanosine cap. Molecular and Cellular Biology, 21 (11). pp. 3632-3641. ISSN 0270-7306

Gallie, Daniel R, Ling, Jun, Niepel, Mario, Morley, Simon J and Pain, Virginia M (2000) The role of 5 '-leader length, secondary structure and PABP concentration on cap and poly(A) tail function during translation in Xenopus oocytes. Nucleic Acids Research, 28 (15). pp. 2943-2953. ISSN 0305-1048

Morley, Simon J, Jeffrey, Ian, Bushell, Martin, Pain, Virginia M and Clemens, Michael J (2000) Differential requirements for caspase-8 activity in the mechanism of phosphorylation of elF2 alpha, cleavage of eIF4GI and signaling events associated with the inhibition of protein synthesis in apoptotic Jurkat T cells. FEBS Letters, 477 (3). pp. 229-236. ISSN 0014-5793

Bushell, Martin, Wood, Wendy, Clemens, Michael J and Morley, Simon J (2000) Changes in integrity and association of eukaryotic protein synthesis initiation factors during apoptosis. European Journal of Biochemistry, 267 (4). pp. 1083-1091. ISSN 0014-2956

Fraser, C S, Pain, V M and Morley, S J (1999) Cellular stress in Xenopus kidney cells enhances the phosphorylation of eukaryotid translation initiation factor (eIF)eIF4E and the association of eIFeIF4F with poly(A)-binding protein. Biochemical Journal, 342. pp. 519-526. ISSN 0264-6021

McKendrick, Linda, Pain, Virginia M and Morley, Simon J (1999) Molecules in focus: translation initiation factor 4E. International Journal of Biochemistry and Cell Biology, 31 (1). pp. 31-35. ISSN 1357-2725

Fraser, Christopher S, Pain, Virginia M and Morley, Simon J (1999) The association of initiation factor (eIF)4F with poly(A)-binding protein is enhanced in serum-stimulated Xenopus kidney cells. Journal of Biological Chemistry, 274 (1). pp. 196-204. ISSN 00219258

Morley, Simon J, McKendrick, Linda and Bushell, Martin (1998) Cleavage of translation initiation factor 4G(eIF4G) during anti-Fas IgM-induced apoptosis does not require signalling through the p38 mitogen-activated protein (MAP) kinase. FEBS Letters, 438 (1-2). pp. 41-48.

Clemens, Michael J, Bushell, Martin and Morley, Simon J (1998) Degradation of eukaryotic polypeptide chain initiation factor (eIF) 4G in response to induction of apoptosis in human lymphoma cell lines. Oncogene, 17 (22). pp. 2921-2931. ISSN 0950-9232

Morley, Simon J and McKendrick, Linda (1997) Involvement of stress-activated protein kinase and p38/RK mitogen activated protein kinase signaling pathways in the enhanced phosphorylation of initiation factor 4E in NIH 3T3 cells. Journal of Biological Chemistry, 272 (28). pp. 17887-17893. ISSN 00219258

Morley, Simon J, Curtis, Penelope S and Pain, Virginia M (1997) eIF4G: Translations mystery factor begins to yield its secrets. RNA, 3 (10). pp. 1085-1104. ISSN 1355-8382

Rau, Michael, Ohlmann, Theophile, Morley, Simon J, Pain, Virginia M and Leung, Esther (1996) A re-evaluation of the cap binding protein eIF4E as a rate-limiting factor for initiation of translation in reticulocyte lysate. Journal of Biological Chemistry, 271. pp. 8983-8990. ISSN 0021-9258

Ohlmann, T, Rau, M, Pain, V M and Morley, S J (1996) The C-terminal domain of eukaryotic protein synthesis initiation factor (eIF4G is sufficient to support cap-independent translation in the absence ofeIF4E. EMBO Journal, 15 (6). pp. 1371-1382. ISSN 0261-4189

Book Section

Morley, Simon J and Coldwell, Mark J (2007) Matters of Life and Death: Translation Initiation during Apoptosis. In: Mathews, Michael B, Sonenberg, Nahum and Hershey, John W B (eds.) Translational Control in Biology and Medicine. Cold Spring Harbor Laboratory Press, pp. 433-458. ISBN 9780879697679

Morley, Simon (2001) The regulation of eIF4F during cell growth and cell death. In: Rhoads, RE (ed.) Progress in Molecular and Subcellular Biology. Signaling pathways for translation: Stress, calcium, and rapamycin. Progress in Molecular and Subcellular Biology, 27 . Springer-Verlag, Berlin, pp. 1-38. ISBN 9783540417101